Flower CT*, Liu C*, Chuang H-Y, Ye X, Cheng H, Heath JR**, Wei W**, White FM**. Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition. bioRxiv. 2024;581004.
Resolving the kinetics of drug-induced adaptive signaling in BRAF-driven melanoma cells.
Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM. High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors. Cancer Res. 2021;81(9):2495-509.
Relative abundances of tyrosine-phosphorylated peptides measured by targeted mass spectrometry in 31 human colorectal tumors.
Shaaya M, Fauser J, Zhurikhina A, Conage-Pough JE, Huyot V, Brennan M, Flower CT, Matsche J, Khan S, Natarajan V, Rehman J, Kota P, White FM, Tsygankov D, Karginov AV. Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife. 2020;9:e60647.
Principal components analysis and protein-protein association network depicting phosphoprotoeme dynamics in cells with light-activated Src kinase.
Flower CT, Chen L, Jung HJ, Raghuram V, Knepper MA, Yang CR. An integrative proteogenomics approach reveals peptides encoded by annotated lincRNA in the mouse kidney inner medulla. Physiol Genomics. 2020;52(10):485-91.
Mouse genome browser visualization of an RNA transcript (black) annotated as long intergenic noncoding RNA (lincRNA) found to be expressed in the mouse kidney by RNA-seq (purple). The short protein encoded by its open reading frame (blue) contains a tryptic peptide (red) that was detected by mass spectrometry.
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